Determination of organonitrogen compounds in air using liquid chromatography and mass spectrometry — Part 1: Isocyanates using dibutylamine derivatives

ISO 17734-1:2006 gives general guidance for the sampling and analysis of airborne isocyanates in workplace air. The method is suitable for the determination of a wide range of different isocyanates in both the gas and particle phases. Typical monofunctional isocyanates that can be determined are isocyanic acid (ICA), methyl isocyanate (MIC), ethyl isocyanate (EIC), propyl isocyanate (PIC), butyl isocyanate (BIC), and phenyl isocyanate (PhI). Typical monomeric diisocyanates include 1,6-hexamethylene- (HDI), 2,4- and 2,6-toluene- (TDI), 4,4'-diphenylmethane- (MDI), 1,5-naphthyl- (NDI), isophorone- (IPDI), and 4,4'-dicyclohexylmethane diisocyanate (HMDI). Multifunctional isocyanates that can be determined are typically oligomers in polymeric MDI, biuret-, isocyanurate-, and allophanate-adducts and prepolymeric forms of isocyanates.