ISO 19290:2021Published

Cigarettes — Determination of tobacco specific nitrosamines in mainstream cigarette smoke — Method using LC-MS/MS

Cigarettes — Dosage des nitrosamines spécifiques du tabac dans le courant principal de fumée de cigarette — Méthode par CL-SM/SM

A new edition is under development: ISO/DIS 19290.

Abstract / scope

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Life cycle

Replaces

ISO 19290:2016WithdrawnCigarettes — Determination of tobacco specific nitrosamines in mainstream cigarette smoke — Method using LC-MS/MSInternational Standard · Published 28 Nov 2016 · ISO/TC 126

Replaced by

ISO/DIS 19290Under developmentCigarettes — Determination of tobacco specific nitrosamines in the mainstream smoke with a smoking regime according to ISO 3308 (standard smoking regime)— Method using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS)International Standard · ISO/TC 126